Site size is always an issue e.g. the more unique content / pages a website has the more diversity they have. In generally don't "check" anything on initial "optimization" but add cookie based tracking code (e.g. hitslinks, indextools, or extreme-dm.com/tracking/ to name a few), and use the referrals from here to define what pages you want to target for what terms. (e.g. someone doing a deep search and finding you is more productive than you searching/checking all pages yourself).
Also find that even in small sites (6 - 25 pages) you can quickly add highly relevant and very effective "ranking" content early to a sites development without even knowing anything about the sites real topics, markets or industry.
A glossary of terms are highly effectly and the online resources (many non-copyrighted and royalty free) is a copy and paste process with only time to add links back and forth between the original site content and the 27 pages of terms (glossary index, and A - Z).
Also if you have PDF design capability that same glossary can be quickly converted to a PDF version and open for download. With your embeded absolute URLs in each glossary terms you receive 100's of new backlinks, PageRank and relevancy for every single site that add this to their site (an added value resource).
Friends - Can you post some more instructions on how to deal with site size?

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